Playing in the role of Hayden Tenno, an unscrupulous covert operative sent on an assassination mission into Lasria � a fictional Eastern European city on the brink of ruin and rumored to be contaminated by a mysterious and frightening plague, Hayden takes out his mark, but before he can escape is attacked by an unknown enemy. Not killed outright as expected, he is instead infected with the virus that is causing the plague. Now, Hayden must learn to evolve along with his powers, to survive and to become a hero. But regardless of his choice, he has become the target of both the blind rage of his fellow mutants and a shadowy paramilitary group that seeks to control them.